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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '916508269944e1aa704b6400a5c0aaf29817f367b62a6e0e1f0bd0cfb0f06597' 
  AND token = 'yZ7+5KZNm5vvI+xmfFqNT+uTNZPDkCcAsXNLt4kLxTI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}