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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1253d58f53c6d037de258a18aace9c727cf9f504094c37665be3796a46ec2a40' 
  AND token = 'FpWLll9G86amTvPBnZp64rAo1UlTtr7luEPug6Z0zmk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}