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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8e760e3796ed3873ea32e2a17ab1984d1e897fbd70547af65220f9f649f3345' 
  AND token = 'anw9+EPt8Ip2DGz0L1G9vxmQ/hdI5GGkr+wK0wbgE/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}