SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649ba37c97d3f481d75f275a90ad07be1106a20a940c3c93fada4b30cac67460' 
  AND token = 'mLdnstlieaZ6KwG1E6ZtgU7+IZ/tamvR/MTyaC1aLpk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}