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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '188fa127b203b80bed251d026b062c55f2a4c79cb9739d5b5d8d86df0da4156c' 
  AND token = 'skB+CKPI7ZdMrVnIMC2Nm6SK39CyqADw9HGBPBR2mg0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00053

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}