SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3783d337754f41137b47044f02d10c8f5ac51b4bff3690e50db85198fa9da927' 
  AND token = 's1B4wQt5Bf+pU5ML0WkPEqEWFBhj75hdZa5TpyetSCI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}