SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4074e49d0dd618f7ec815788b6e257deffcc5bdfc4544e5fd5cbfecde756585c' 
  AND token = 'K4CLtaIboDqdp91ht3RZFEt36Dh/eA9EYmFZcwr/aw0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}