SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e05a9e8d736c8373d526a81c4614e2f950e03b71eb6c5e69f235ebe98452c68' 
  AND token = 'S/9I6gsQxfxY5tjl3uCsn3xWZ4vjhHmEhWkzR7i0BIg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}