SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '440580cf7759a7202f23b67ab94c5c638f859032f1633bb0ab12af1edf661dac' 
  AND token = 'yyjAGTvIP7W/2s1lfhTfbt1oDF+gbAWaH3i9ciUZgVk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}