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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ef5bb0341c40499a84e0498991c10b816a7bb5f693a7ce680d39dfb7ad065b' 
  AND token = '7rCMWCIGwjhuvXQxmY/irE4hC9xd2mbiyBdrp9aG7sQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}