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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e3be9cb949bb2ad02ac32b267b96e3916f1520954581368fa3c25c57f78f3cea' 
  AND token = 'expOP7adlrWfvS03vQKxBe4s6qMa51nCRjlZZId3PoA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}