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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e8f30383cb8e5a3e64ffda3ddb3371adc777484e991e5b83521b376c00fb373' 
  AND token = 'KXbR3Vi8xDy9OF+2jzJRXuMzxc8eXcAhb2BdmmKuM98=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}