SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a75b2187ae8b019fffcd63f69a4f97046ccc5fd219b485b102ef3d7c15380459' 
  AND token = 'TA1CSaL/3DaQuYjGa6RUCOHvCmx1o1KN9NuUi3d7fe8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}