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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '742250ae7f2397f42e618ecda5f6aeb65a1d3db3ce09324bede3456d67ee76a4' 
  AND token = 'TZOBSAvrqF1hZ+XwCUGocO3qzBr99bxf59A4bdFCL+M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}