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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '437dff2b6533c8c2c2503b1f49d8363a5bca84b277e5c1953a29f451bf05137a' 
  AND token = 'tFZx4uVuN7spXcuPLC4tTeUKfZRmdNUm3dJHlzcrXUM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}