SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378ba1915987424113b6988af6e8595627470dd543e95dbf614ff48a823ffdd1' 
  AND token = 'NHu6OiRdUDFcD4Ppkl3THMDyJW1DUTA+qyQo4+tjY6M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}