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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd260f3b4f01100d545df10ee1a6a491852ab10fd2ad32e96f15a5914813704e7' 
  AND token = 'p/y+xcc/d+txnvLdQbZhg5qpLT+bXiRvWCw+90cM0v4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}