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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c45719bfabfaad8e377405313f8c221b6fba1f2467373f4587bf278fc310d1f9' 
  AND token = 'TXrk5IvTZrrwe8eSiN+S3NnQbC5sEj8fPdyRYL27eZQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}