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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2021c1b0a4ec7e023aec70e61d16f8ad895d2e04e3b5ccb72b917a1c99420add' 
  AND token = '4nbvLcOGVj9YvNZI9on7fxLRnLzn7LEBHS6yA7HpyhQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}