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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1887d4b8d9fd18370d14fbab6344ba2da22f561eedbb20a8399dfff8ddb66246' 
  AND token = 'xOzpqIwek+9+bnXy/OmAvI3qpi7M5RIQmLA5JS9Y/YE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}