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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b0035290982a4f0d7968bfbc55fd8debff18c1b0792a69fc57ede496b1f328' 
  AND token = '0THIopyXF32RPw7y7/0UzJ4D+hubN6YA1xqU8nb6tNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}