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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a290a09412c493cb740e3d7edc4bcfffdc76f80bb70597365c87a8267f960c3a' 
  AND token = '2CmKdMTEAHVVq5oTFKlFiCSAtVTV6P/2Nzjb1kgRMfA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}