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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ab2452a532b15965f3057d9fbc636c08ff4205940fc0b91aabf01e94a27b42' 
  AND token = 'gMGs3IVlqK9KaTpmkN+CDnHsdwwa2snn2ULGyoP2mAw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}