SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '861b9fdcbb4c1727e7959eae3c41b9dd3ef03cc8a1c8c30277b877c7de95f12a' 
  AND token = '6438RHw0OLspfrgdGlUXHVTDl7nVzRtsaGTY+JNLCs0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}