SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c320a538037c113331f7fecf773feaa4a0c04de181f7fa7393486ef77653f270' 
  AND token = 'UOfEZjPQH00cL1nT/lPdxXNiRkyBek982D4JxntLaJk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}