SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cbd450cf74c2eb977b644a017dfb8c644c0f76c4a50a454e719739863b443225' 
  AND token = 'vfB75xokckfgWu9h1x71ROkHzdnFwri416lTAWWimEs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}