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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '10fba3b9c08626aea6f70bbec1a3d6a51ec3c1458616626362408fb4e3a1cec0' 
  AND token = '46HCpTFmsmaUfKXDBiJAXA878wg9liK+EdR9753kDaA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}