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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8c17a700b7efd8c5a310ff8d6173be74c9c75321589eaf11fed5bffe8bd56e5' 
  AND token = 'sUkJiC4XyeR3RA45W2wDUpZbDkLFm4djZ4OcpcOLs3c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}