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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75fc53f38ceba2a0dd7f4f4af243fcef9495d8a77e0b22ce58858ef6786f1644' 
  AND token = '16IzmKUzJ4+cWaIe8df1UVOV5pkvqKTTyczXg3hK2eI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}