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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9e191ad0a2e7e5c1805a5649320be01c34e98d008fb8e3507435da06c23dc4d8' 
  AND token = 'UanBDM4IOvCT6iHmW3Sx4mZVvjPw1bXK+U9cOHNlT7s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}