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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9745363affc00896acf89884df5c0f47daf18eff9949fa8b9ce15d18657d23d3' 
  AND token = '70BTCtj1VXmYcLjeZXRHKhDRNeJ7uY6YWfmBYFp0Hbs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}