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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46c0db228ac64f4e5d3144f2c8277ef45f3b20def68104db53f3d22dd2e04724' 
  AND token = 'Rdac66fOVnB6ia/p6aPi34AxasaUy8MRhvDGlNs+cHw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}