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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21fa34f038b672b393599f40a21b878a8aab2245c592068e32b0fd717e9101c3' 
  AND token = 'kUeACCZTO9Lzp0zFBnwpZuBAjOhntRYzhtcT3Rv0XNU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}