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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5188f28ae239450ce3344edc5cd4ebf2915d3ae23d66aa2134d8952c37d1da9' 
  AND token = 'ys8lfCGAj1GbxmAFlp4UvEMAF/IpE0YhrzDyPrz3wqo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}