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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '243b4ac48b9075122c847f442d2af415a9689b01869506926be1e3adf84e606f' 
  AND token = 'Wtuh8n8y7lTYMnsQIPwC+KfkS1tR8N55t8K4htkFZQA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}