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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e45bae681e4ffafc96654c4fd2b307a25d2b7cf5f361c3997fe5f1142221e062' 
  AND token = 'eKGcO/5cXXiYdtjmQb9WfpUHHDaCcX3Vc3lik8l0RPc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}