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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43ddf20f1aaafecd43f203918e28bf2812a05522a250ec967b0b5d159558f738' 
  AND token = 't4ZuISIpJMLcsN+Q+w9XqZeGq2keaQx5S1NRUllIPEA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}