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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46c4802b5443c4433ba007de98620df92724afa81fd486cc553ca020a5f5a950' 
  AND token = 'A/kn9vMhsIxz96kdIpLcH3njjmmxIUc0v9UIFz9+iUk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}