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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d74cef48ddd2a0a52b11d8fdea49eac7272a295838ea934629da4cf0fe27772' 
  AND token = 'gH6rx5jPf1eB2ONJ2+WGrZlOLbFaG7stXWs4oltOJJA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}