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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '04e2fcd642b59996c8b4466a03ace9cbb3d49ebad244870a76f15d059019a61c' 
  AND token = '+3Du+OD58WfjJNS71uzpyOhaoYBVnF2jnxUGbRfPHe8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}