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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b2acbaf208956211d30e0d0ca38fc5449e7a5fc40000922ce740020e481b1c4' 
  AND token = 'WXB4fHUd6p20ZT/fHU7yAqa+C3cL0K02ZypwUZ2pJu0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}