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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1cacb23f08b54a511487ef73a48b823cbc20651b9ccc8c3138a2a00da083c797' 
  AND token = 'ENj2XA3NB9DUJpOIhBXfV3Pj8NtVEkSupvHSBGIxc5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}