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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b9c3760b4034818e3b79089c1d09508620a3d8406e29e167d84aa5be6339152' 
  AND token = 'AEiUbRWLYPls3bM9h5EjfC4PSaN61zT4qM+j1ugUXiI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}