SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d7cc0e567a1fb96013aa45e620eaf55fa2ea42769fb27d2a379761319e818e' 
  AND token = '+nUFmGgOyt61qk4xOdi31PDEDwPn5JXskje3Qr3LBDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}