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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fec7a4e365432e0a3ffb6531d740f74033b69eca0b5046e08c976f927774c752' 
  AND token = 'syZ5Am+fIcS/W+bmn3J8TthzVbJdGX9rfXd4NMX4Qjs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}