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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6449da6be74c84804f68b6f9a25e71be7a927c87e27ee8888e4d090b94f2d270' 
  AND token = 'oKmk9begGRXRzrIc6t3/Wi7VT8qM5s8kKI/uDsibatU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}