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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3625e6881be42e6f9f874e84bf3bfd2b74686ef77d43b00f40d76b15debd0019' 
  AND token = 'AP5sTbweH6x6ZbRtiNEL/5F6h+9b5kS5YyS6D25WkeQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}