SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '159408e2bf59a0fb7a699687e95740b5abc2470da586d75d168bd59c1dc9b3a2' 
  AND token = 'LAryMlmqQQ+uBSxea8LA4z8EQtYDuNPm85xml76E29A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}