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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d980c2c89d4398a78bb457c576f5de0b5ed8727d28dcc5da1626ed83f65996' 
  AND token = 'U/AVYsOg6EP7P7+Uqtbxe7DwI3UXmI5QnqkM76RTlW4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}