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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78bec79b1874afb32818f42e4377cc608916fb5b0d37d7e5dce23cd8bf9e51ac' 
  AND token = 'tiSIgC7xypnQUVv0RmCA0iyqpLiTtBOv4608nc6t/AY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}